dr. frieden? guest: sure. both important issues. drug-resistant microbes are a real threat and we have seen them increasing, and a pipeline of new antibiotics is running dry. there have been actions in congress to try to increase incentives for companies to make antibiotics. the national institutes for health is funding research on new antibiotics, and another department of health and human services is funding work on new antibiotics, it is difficult to bring new at the biotics to the market. it will be challenging and we have to preserve the antibiotics we have. we need to be good stewards of our resources, and we have recommended at cdc that every single hospital in this country haven't antibiotic -- have an antibiotic stewardship program, which could save the money, and more importantly prevent tears competitions, and reduce drug- resistant. antimicrobial resistance will take everyone, patients realizing it is not the best thing to get antibiotics, doctors standing firm if there is not a need for antibiotics, hospitals and health