a the security council unanimously approved new sanctions on pyongyang restricting oil imports and banning textile exports to the ocean of sin generalization against my country is an extreme manifestation of years and years intention to eliminate at any cost to ideology so socialises team of d.p. r. k. and his people such act constitute ople and don't infringement of the so wintry of my country and grave challenges to international peace and justice and bangladesh's prime minister has visited red to muslim refugees who come from myanmar and promised that our country will take care of them so far three hundred seventy thousand ranger across the border looking for refuge from what united nations says amounts to ethnic cleansing a prime minister shake us here also said myanmar will have to take them back one

day tech now is coming up next that's it for myself and the team here in london by now. it's not just phones contributing to samsung's bumper profits if we look at the u.s. economy the moment it does seem to be in pretty good shape up until around two thousand and five greek debt levels were basically stable we bring you the stories that are shaping the economic world we live in counting the cost on al jazeera. like a cancer diagnosis that used to leave little room for hope. says the eighteen hundreds doctor suspected the body's immune system might told to chill for this stuff and. that no one could crack the complex code and until this scientist did. now this is the new face of cancer patients who are living proof of a cure. this is technically

a show about innovations that change nights we're going to explore the intersection of hardware and humanity and we're doing it in the unique way this is a show about science by scientists. and welcome to tech there in paris i'm dr judy for mara and we're hare but it's them incredible work that is helping to fight and even cure cancer it's called i mean i think a liver cancer treatment that turns the body's own fellow into chuma killer. is an innovative field of research and is changing lives all over the world but we follow one man's amazing journey for tech nerds here's dr christo there was. david white is about to do something he has done more than one hundred and twenty

times to come from anchorage alaska every two weeks he will leave his home in one of the most remote american. cities and fly more than five thousand kilometers to houston texas normal treatment i believe. five in the morning. back. and forty four hours two days. it is a better life and death. david is an experimental cancer program at m.d. anderson cancer center in houston texas it has kept him alive well beyond the prediction his doctors gave at the beginning you didn't think that you would be able to have sex without. gaining the best anybody would give maybe. twelve to

twenty months. much time to get your affairs in order. and it certainly doesn't give you time to. do what you want to do with your family and children. david has bladder cancer he was first diagnosed in two thousand and ten when doctors found a small tumor on the wall of his bladder. it's pretty scary and then yeah i think it's a small it's less and. they cut it out and the thank you through but you aren't we took this serious surgery we removed my bladder and. we thought so but it didn't happen my cancer came back in a year where it was wrapped around my colon and i had a big tumor. that was in two thousand and eleven. underwent chemotherapy and an experimental gene therapy treatment but the cancer kept spreading to his left lung in two thousand and thirteen then in june of two thousand and thirteen he began the

experimental immunotherapy program now david has kept alive by his strong will i think we better start. one thirty years. and the drug in this infusion bag. nancy pinkston is on the same drug she was diagnosed with stage three melanoma in february two thousand and sixteen there was showering. and. right doctor calling at night and telling you it's not on. it it's a game changer that was almost a year ago. their labs looked perfect for me i wanted to live and i thought this was my best chance. is also part of an experimental therapy treatment at m.d.

anderson she began treatments in march of two thousand and sixteen she had her tumor removed surgically in may her oncologist. are you surprised by how well the thank you very brief surgery these treatments are you know absolute game changers and for nancy the change came quickly and i saw the body you think your hand that is and want to say first some other nonsense and i think it's a little smaller and i examined it was at least thirty percent smaller and i was pretty excited. it was a moment because i'm surprised how fast you have to want to treat. it sees such a big difference and the tumor one two pathology there was not a single viable solvent not a single cancer cell which is you know amazing. it is. and found that there was. a little more of a brain. nancy first heard about immunotherapy when a former u.s.

president announced he had melanoma that had spread to his brain and was being treated with a hard to pronounce drug named elizabeth i want all of you to remember that name. just a few months later president jimmy carter said he was cured when i went this week they didn't find any cancer at all from what i read there. are. different for like jimmy carter. things are the same thing and so he explained forming some drug different manufacturers. this new wave of cancer fighting drugs called immunotherapy come in part from the lab and the brain of the scientist dr james alison and his partner and like dr. allison breakthrough actually changed the whole field i mean what he recognizes that time doesn't just have on switches it also has off switches that say yang and

the yang and then man says that if you keep trying to turn it on it has its own internal controls to keep it turned off and he recognized that if you want to really turn. so you turn off the off signals the blocking the brakes basically and he developed the first antibody this way which is enticing tele for because he identifies the tele for as the off signal or one of the off signals now we know there are so many and by blocking see telling her what an antibody we are able to get the t. cells now to go and keep killing tumor cells and that's why some patients can have these responses so now there's a whole field called the mean checkpoint blockade and that's immunotherapy that we know of today in the clinic. the human immune system is built around white blood cells scientists call t. cells these molecules are so tiny they can't be seen by the human eye this image from an electron scan shows a healthy human. senses an infection it will attack it with many cancers t.

cells won't attack because the tumour cells are blocking their talking mechanism. immunotherapy overrides those blocking systems allowing t. cells to do their job. like a little more and yes it is i do think it's a war of the you know to terrorist cells and the immune system are battling right the tumor cells are trying to get everything to surround the to protect it and they mean system keeps trying to attack and then when the tumour cells have all of the right things to protect it they mean system a sort of disabled and it can no longer function and what we're trying to do is reach energize the immune system so they can get through all the barriers that the two missiles were put up to kill sooner so cancer has largely been winning the immune system or until now we have clinical trials ongoing and prostate cancer bladder cancer kidney cancer leukemia for example c.l.o. for example lymphoma is. pancreatic cancer breast cancers

color rectal cancer varying cancer and so what you're trying to do with each type of cancer is kind of tune that on off for the immune system. find that right balance for that cancer exactly and sometimes we don't find the right balance. is unique but more than human clinical trials and thousands of patients they can test . results from biopsies. is currently running a study on. immunotherapy has not been effective. and so we've got this great. trade into. this inhibitory right. now the. expression. that. it's a protein that. scientists call this immune inhibitory. dr sharma showed us winning the war. drugs infiltrating the tumor but the.

expressed tumor was not shrinking and the cancer not going away all of these little blue dots are individual tumor cells and then over here on the side of all of these colors trying to fight the tumor but the white standing here tells you that the tumor is a little ways like fighting back at. that. point therapies are really block these off signals. because these are all off signals that are now been identified in the t. cells so we think we need combinations strategies for prostate cancer. you got a pretty good understanding you know for example of prostate cancer which was. very responsive for the therapy. improved we generated.

about. her of course a real number of her sure. which are very strong. from the patients who go there to make the patients arrive here the we we started to work was really instrumental and kind of elucidating those checks and balances that exist in the immune system. and how do you get from that to a therapy well. first of all frustrated with two cells which i was an undergraduate actually when i first discovered a really good or i don't know what was it about. just to know should you have the cells are you all over your body or protect your home it's just so cool. to me that was i thought this might slow but to remember that we have to do a lot of combinations to get the word but it turned out of many terms you didn't have to just a single injection we had a body that was so you and dr allison are married yet when you came to have your

spouse in the lab with you working in the same field i think of myself as very lucky you know clearly i'm passionate about the work that we do jim and i talk about t. cells more than i think any two people in the whole world. you know we get up in the morning talking about it we go to sleep talking about it it's what drives us because. there is a new pill or an immune checkpoint therapy is really what is now showing all of this benefit we think other immunotherapy will do that as well including adopted. and these other ways of engineering that before giving them back to patients you wouldn't think of chemotherapy surgery radiation therapy without adding any therapy any more you've now changed that whole paradigm yes i'm i'm very proud i think you know. it's his passion that i fell in love with to be honest and it's been his passion that drove the work he wanted to see whether or not what he did in the

laboratory his basic science could have clinical impact and he drove that i have to say there were many people who thought that all you're going to take an antibody and block this single molecule and you're going to treat dancer come on give me a break that's not going to work right he got a lot of rejections along the way and he stuck with it but it worked out for everyone not you know not just his signs or his career but it worked out for so many patients. for some of those patients like david white life has been extended beyond what anyone imagined but it comes with a price infusions come by weekly or paid for by the drug company sponsoring the study but the trips are tough all of this is emotionally hard i think emotions are harder than the physical part so you've had some pretty amazing results on this immunotherapy can you tell me about that. i just you can get lucky. i got responses and six weeks to the a mentor and i haven't had

a recurrence of my cancer in. two years at age seventy two two years have made a huge difference. yes. and what do you want to do now. ok i gave up running but i still coach and read for you so. thanks again guys thank you yes to young children who are never far from his thoughts is hard to talk about. so when i got cancer nicholas was and. was about it was for. snow or you want to be with little kids. but they're a big part of my vote up as should. do i get a hug before i leave. i

felt like my job and. so necklace is now. sixteen he's edgy and here. i'm isabel and she's going to be eleven and end of this year and she's that have critter big difference. i've been able to be and often to have an influence on their development in life quite a bit it's not something. that she does fun coaching things. and with the outcomes we've got right now arm i'm hopeful that it's going to be a lot longer at least relative to this part of the disease. so i mean not only did he have a complete remission where we essentially cannot find the tumor back on c.t. imaging he's had a very long term durable remission that's now ongoing for more than two years of

treatment for his labs and the other types of reports that you look at do they look very similar to someone of his age that never was diagnosed with cancer. over time have become more normal more what i've seen in the typical population and so clearly the effects of them you know their b. are certainly relevant they help him he's feeling better he's doing better and his cancer is under control what percentage of the patients in your trial sort of experience this miraculous recovery so around twenty percent or so patients do very well with these clinical trials so it's not everyone but it is a substantial fraction of people that we couldn't do this far before i mean checkpoint therapy became available that gives us hope that we can build on this twenty percent to make it fifty percent eighty percent maybe one hundred percent i'm not going to sign miracle although it feels like a miracle feels like

a huge blessing. and i think it is i think it. checkpoint and i mean a therapy is just one of the new therapies it seems to work best with cancer is that people get from too much sun smoking. but technique is come to paris because of a new high and. it's called for adoptive cells transfer. scientists take t. cells and genetically edit them this immunotherapy is now undergoing its first test the results are impressive. which year old but she's fighting for her life. just. she was diagnosed with leukemia as the only decision there was no doctors tried everything including a bone marrow transplant so we didn't agree with dominic right to do nothing when i

was a what we don't want no whatever we want tonight that we've tried everything for her life but you gonna just go home and know that there's something available and just think what if we had a child with done it now and i mean. a list doctors made a desperate plea to a biotech company in paris it was a long shot but dr andre shooting was ready god a call from the physician that we're creating and they said we have no solution and maybe this off the shelf prologue could be a solution why because this patient had enough teeth cells the next step in the fight against cancer is happening in the barn this one scientists here in paris a genetically manipulating t. cells essentially engineering them to become cancer fighting its. later received a single dose of genetically engineered t. cells so we shipped the vile there and that was the first time this new party

nineteen which is the fourth problem for acute flown for black people of kenya was those i'm a. strong patient in just a few weeks she went into complete remission and jerry keeps us up late and i think it's already in the morning. yes it's not even started just magic the genetically engineered dose is in this vial it's a type of t. cell therapy called car therapy american antigen receptor therapy the proteins that give t. cells the ability to target human cells and you know this technique was invited inside this laboratory operated by the selectors company to get a close up view of how this gene editing works before us. protective gloves and. so this is the place where you can find place it's block cells the for being manipulating genetically to reprogram them from and to become real cancer killing

or happens head yes it is just the start the entire process would take seventeen days it begins with t. cells the company gets from me. so how is this different we cold it's going to paris targeted because we use molecules with a kind of a warhead the tip these molecules have dialed and program and which are called antibodies it's like a rocket that can recognize. a cell. seeking missile finding the cancer cell that's exactly it so we can actually see the cells being growing hair in the flower yes and i like that are centered on the so-called wafer . so here we have what's called the wave machine named for the gentle motion of the machine designed to help. what happened in the body is totally different

when the key cell gets inside the body it will recognize to become through the camera and to generate scepter it will start lifting the cancer cell the cell that would present for example see the nineteenth and then the t. cell will kill the cell but what it said gets inside your body here is start the war against cancer so here is where you have to. cancer fighting self yes we want to preserve the cancer potential as much as possible and keep them. alive sleep here. in perth any interaction before to get them to war so here where we just. exercise the bed but don't take off my cap. jam exactly it's a it's a jam. and it was on to the most critical step in the process so what's happening

here it's a word a genetic thing will have some load. put the thing ready you saw it floating electricity. it started and then the thing happened it still looks super simple i'm going to read it it happened it's very it's a microsecond the gene editing process happens on a microscopic level that looks like they're. so cool talons come the d.n.a. sequence to suppress certain surface receptor. sounds can then be targeted for specific cancer so now what you have is the time and the impressions of the two sounds to me that you're sitting on now the action against your reaction to storing now and during the next two hours to three hours old a genetic thing will have the trucks hauling for ninety percent of the cells will get the genetic thing not hundred percent. you can't nineteen is useful later

richards he had acute lymphoblastic leukemia a our form of blood cancer. you can't one two three targets eight am for acute myeloid leukemia don't marry cancer. so what do we have so these are t. cells. cells are targeting. and they have been just so they were frozen and we thought them. so we can see the cells. wow there are many cancer soldiers in there it's amazing to think that one of those tiny in the core sounds is a cancer fighter when you see them and actually incredible the idea behind this therapy is to make it viable for any patient because the t. cells are not specific to an individual after gene editing that should be no rejection of. an uncertain revolutionary isn't

a. trial i think that definitely a revolution that is starting its heart of it and cancer but this revolution going around the results. be very promising as of october two thousand and sixteen which it's remains. a second young patient was given that. she has not been identified she is reported mission. but the little girl and her family who are brave enough to risk it to put this treatment. is the one who doctors remember. very happy to take a step we take she came kind of came out painted me. what was that like to be part of that first saw her on t.v. i think just like i was drawn like a pretty strong emotion in

a world like this is like the most beautiful thing i've ever done in my life and if it has to stop here well at least i've done something. the water back integration needs to be tested to find out if they are confident that when it is i can secure could be a reality attack carol i'm dr city so mara and paris for you next time. a new level of luxury has arrived. an experience that will transform the way we treat. our impeccable service remains but none comes breaking. business plans. the poultry for the sea the finest. weather conducting business sharing

a special journey. when the first of. the certainly that. saddam was in and trying some of. your centuries in the sky. traducing to say. this to. cannes only we're going places together. right.

from the icy mountain steps of mongolia to the flooded lowlands of south america. the high stakes series returns. following the daring journeys of ordinary people from around the globe who take extraordinary risks to earn a living. risking it all coming soon on al-jazeera. this is al-jazeera. you know i'm rob matheson this is the news our live from doha and coming up in the next sixty minutes the death toll from hurricane a rises as officials across the.